Non-right sidedness: an association with lower IL-2 production

Life Sci. 1992;51(24):1843-9. doi: 10.1016/0024-3205(92)90035-n.


Using a laterality questionnaire, 138 normal healthy individuals were classified as right-sided and 25 as non-right sided. Interleukin-2 (IL-2) was generated from whole blood obtained from these subjects using mitogen (PHA) stimulation. IL-2 was quantitated in picograms/ml using an enzyme immunoassay (ELISA). Additionally, sera from these subjects were tested for 7 autoantibodies by standard serological methods. As compared to right sided subjects, non-right sided individuals had significantly lower IL-2 production. Non-right sided individuals with autoantibodies had significantly lower IL-2 production than right sided subjects with or without autoantibodies, but did not differ significantly from their non-right sided counterparts without autoantibodies. These data support the increasing evidence for the differential and lateralized regulation of immune functions by the right and left cerebral regions.

MeSH terms

  • Adult
  • Autoantibodies / analysis
  • Brain / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Functional Laterality*
  • Humans
  • Interleukin-2 / blood*
  • Male
  • Surveys and Questionnaires


  • Autoantibodies
  • Interleukin-2