Meta-analysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori

Am J Gastroenterol. 1992 Dec;87(12):1716-27.


Despite numerous Helicobacter pylori treatment studies, the optimum regimen(s) for its eradication remain unclear. Our objective was to determine systematically which regimen(s) gave the best pooled eradication rates, by using meta-analysis methodology. A total of 27 studies were identified. Pooled eradication rates for single (18.6%), double (48.2%), and triple therapy (82.3%) were statistically highly different (p < 0.0005). Eradication rates with amoxicillin (23.0%) and bismuth compounds (19.6%) were equivalent. Combined treatment with bismuth+metronidazole was better than bismuth+amoxicillin (55.1% vs. 43.7%, p = 0.049). Triple therapy with bismuth+metronidazole+tetracycline gave a statistically higher eradication rate (94.1%) than bismuth+metronidazole+amoxicillin (73.1%, p < 0.0005). Despite increased side effects with multiple antibiotic regimens, patients tolerated these well, without significant drop-out. The combination of bismuth, metronidazole, and tetracycline gives the best eradication rate, but the optimal doses and duration of treatment have yet to be determined. Further studies are necessary to explore factors such as antibiotic resistance and drug compliance as important factors affecting antibiotic efficacy.

Publication types

  • Meta-Analysis

MeSH terms

  • Amoxicillin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use*
  • Bismuth / therapeutic use
  • Cefixime
  • Cefotaxime / analogs & derivatives
  • Cefotaxime / therapeutic use
  • Drug Therapy, Combination / adverse effects
  • Drug Therapy, Combination / therapeutic use
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori*
  • Humans
  • Research Design
  • Sensitivity and Specificity


  • Anti-Bacterial Agents
  • Amoxicillin
  • Cefixime
  • Cefotaxime
  • Bismuth