B and T cell leakiness in the scid mouse mutant

Immunodefic Rev. 1992;3(4):261-76.


Recombination of antigen receptor gene elements (V, D and J) that code for Ig and TCR variable regions is defective in the scid mouse mutant. However, the defect is not absolute. Developing scid lymphocytes occasionally succeed in forming a productive VDJ and VJ rearrangement at two critical loci (e.g., IgH/IgL or TCR beta/TCR alpha), and given the appropriate stimuli, differentiate into clones of functional B or T cells. Scid mice with detectable B and/or T lymphocytes are referred to as leaky. This review considers the nature and possible basis of B and T cell leakiness in scid mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • Clone Cells / immunology
  • Gene Rearrangement
  • Genes, Immunoglobulin / immunology
  • Lymphoma, T-Cell / immunology
  • Mice
  • Mice, SCID / immunology*
  • Receptors, Antigen, T-Cell / immunology
  • T-Lymphocytes / immunology*


  • Receptors, Antigen, T-Cell