Using positron emission tomography 2-deoxy-2-[18F]fluoro-D-glucose, 11CO, and 15O-water for monitoring androgen independent prostate cancer

Mol Imaging Biol. Mar-Apr 2003;5(2):86-93. doi: 10.1016/s1536-1632(03)00039-8.

Abstract

Purpose: Monitoring of androgen independent prostate cancer (AIPC) therapy involves monitoring prostate specific antigen (PSA) blood serum concentrations; however, the reliability of small changes in PSA values has been questioned. We performed a small pilot study to determine whether PET might be a useful monitor of changes during anti-angiogenic therapy in AIPC.

Procedures: Changes in tumor blood flow ([15O] water), blood volume ([11C]CO), 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake and metabolic volume were measured before and during thalidomide treatment and compared with changes in PSA in six patients with AIPC.

Results: The percent change in PSA correlated with the FDG Delta%SUV(mean) (r=0.94, P<0.01) and Delta%metabolic tumor volume (r=0.91, P<0.01) but less well with Delta%blood volume (r=0.65, P=0.14). Percent change blood flow values showed an inverse correlation with percent changes in PSA (r=-0.83, P=0.032).

Conclusions: PET measures of tumor blood flow and metabolism may have use in monitoring the physiologic changes occurring during anti-angiogenic therapy in AIPC.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase II

MeSH terms

  • Aged
  • Androgens / physiology*
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use
  • Carbon Monoxide*
  • Carbon Radioisotopes
  • Fluorodeoxyglucose F18* / pharmacokinetics
  • Glucose / metabolism
  • Humans
  • Male
  • Middle Aged
  • Oxygen Radioisotopes
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms / metabolism
  • Radiopharmaceuticals / pharmacokinetics
  • Thalidomide / adverse effects
  • Thalidomide / therapeutic use
  • Tomography, Emission-Computed / methods
  • Water / metabolism

Substances

  • Androgens
  • Antineoplastic Agents
  • Carbon Radioisotopes
  • Oxygen Radioisotopes
  • Radiopharmaceuticals
  • Water
  • Fluorodeoxyglucose F18
  • Thalidomide
  • Carbon Monoxide
  • Glucose