CSF hypocretin levels in Guillain-Barré syndrome and other inflammatory neuropathies

Neurology. 2003 Sep 23;61(6):823-5. doi: 10.1212/01.wnl.0000081049.14098.50.

Abstract

CSF hypocretin-1 was measured in 28 Guillain-Barré syndrome (GBS), 12 Miller-Fisher syndrome, 12 chronic inflammatory demyelinating polyneuropathy (CIDP), and 48 control subjects. Seven GBS subjects had undetectably low hypocretin-1 levels (<100 pg/mL). Hypocretin-1 levels were moderately reduced in an additional 11 GBS, 5 Miller-Fisher syndrome, and 1 CIDP subject. Low levels in GBS occurred early in the disease and were associated with upper CNS level abnormalities.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Carrier Proteins / cerebrospinal fluid*
  • Female
  • Guillain-Barre Syndrome / cerebrospinal fluid*
  • Guillain-Barre Syndrome / complications
  • Humans
  • Intracellular Signaling Peptides and Proteins*
  • Male
  • Middle Aged
  • Miller Fisher Syndrome / cerebrospinal fluid*
  • Neuropeptides / cerebrospinal fluid*
  • Neuropeptides / deficiency
  • Orexins
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / cerebrospinal fluid*
  • Quadriplegia / cerebrospinal fluid
  • Quadriplegia / etiology
  • Single-Blind Method
  • Sleep Wake Disorders / cerebrospinal fluid
  • Sleep Wake Disorders / etiology

Substances

  • Carrier Proteins
  • HCRT protein, human
  • Intracellular Signaling Peptides and Proteins
  • Neuropeptides
  • Orexins