Xpd, a structural bridge and a functional link

Cell Cycle. Nov-Dec 2003;2(6):503-6. doi: 10.4161/cc.2.6.558.

Abstract

Xpd, one of nine polypeptide subunits of the general transcription factor TFIIH plays an organizing role in TFIIH assembly. This structural function in protein complex assembly appears to be used by cells in a dynamic way to regulate and co-ordinate the diverse cellular functions of the different sub-complexes in transcription, DNA repair and cell cycle progression.

Publication types

  • Review

MeSH terms

  • DNA Helicases*
  • DNA Repair
  • DNA-Binding Proteins*
  • Humans
  • Macromolecular Substances
  • Mitosis / physiology
  • Mutation
  • Protein Subunits / chemistry
  • Protein Subunits / metabolism*
  • Proteins / chemistry
  • Proteins / genetics
  • Proteins / metabolism*
  • Transcription Factor TFIIH
  • Transcription Factors*
  • Transcription Factors, TFII / chemistry
  • Transcription Factors, TFII / metabolism*
  • Transcription, Genetic
  • Xeroderma Pigmentosum Group D Protein

Substances

  • DNA-Binding Proteins
  • Macromolecular Substances
  • Protein Subunits
  • Proteins
  • Transcription Factors
  • Transcription Factors, TFII
  • Transcription Factor TFIIH
  • DNA Helicases
  • Xeroderma Pigmentosum Group D Protein
  • ERCC2 protein, human