Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids

Anticancer Drugs. 1992 Oct;3(5):525-30. doi: 10.1097/00001813-199210000-00013.

Abstract

We investigated the antiproliferative effect of two polyhydroxylated (quercetin and taxifolin) and two polymethoxylated (nobiletin and tangeretin) flavonoids against three cell lines in tissue culture. Tangeretin and nobiletin markedly inhibited the proliferation of a squamous cell carcinoma (HTB 43) and a gliosarcoma (9L) cell line at 2-8 micrograms/ml concentrations. Quercetin displayed no effect on 9L cell growth at these concentrations, while at 8 micrograms/ml it inhibited HTB 43 cell growth. Taxifolin slightly inhibited HTB 43 cell growth at 8 micrograms/ml, while moderately inhibiting HTB 43 cell growth at 2-8 micrograms/ml. The proliferation of a human lung fibroblast-like cell line (CCL 135) was relatively insensitive to low concentrations of the above flavonoids.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Squamous Cell / drug therapy*
  • Carcinoma, Squamous Cell / pathology
  • Cell Division / drug effects
  • Cell Survival / drug effects
  • Cells, Cultured
  • Embryo, Mammalian / cytology
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Flavones*
  • Flavonoids / pharmacology*
  • Flavonols
  • Glioma / drug therapy*
  • Glioma / pathology
  • Humans
  • Lung / cytology
  • Lung / drug effects*
  • Plant Extracts / pharmacology
  • Quercetin / analogs & derivatives
  • Quercetin / pharmacology
  • Tumor Cells, Cultured

Substances

  • Flavones
  • Flavonoids
  • Flavonols
  • Plant Extracts
  • Quercetin
  • taxifolin
  • nobiletin
  • tangeretin