Amino acids and the humoral regulation of growth: fat bodies use slimfast

Cell. 2003 Sep 19;114(6):656-8. doi: 10.1016/s0092-8674(03)00721-9.

Abstract

The mechanisms by which animals coordinate the growth of different tissues in response to nutrient levels is poorly understood. In this issue of Cell, Colombani et al. demonstrate that amino acid-responsive TOR signaling in the Drosophila fat body modulates insulin signaling and growth in peripheral tissues.

Publication types

  • Review
  • Comment

MeSH terms

  • Amino Acid Transport Systems / deficiency*
  • Amino Acid Transport Systems / genetics
  • Amino Acids / deficiency*
  • Animals
  • Drosophila Proteins / deficiency*
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / growth & development*
  • Drosophila melanogaster / metabolism
  • Fat Body / cytology
  • Fat Body / metabolism*
  • Food Deprivation / physiology*
  • Larva / cytology
  • Larva / growth & development*
  • Larva / metabolism
  • Phosphatidylinositol 3-Kinases / genetics
  • Phosphatidylinositol 3-Kinases / metabolism
  • Protein Kinases
  • Signal Transduction / genetics
  • TOR Serine-Threonine Kinases

Substances

  • Amino Acid Transport Systems
  • Amino Acids
  • Drosophila Proteins
  • slif protein, Drosophila
  • Protein Kinases
  • Phosphatidylinositol 3-Kinases
  • target of rapamycin protein, Drosophila
  • TOR Serine-Threonine Kinases