COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases

Cell. 2003 Sep 19;114(6):663-71. doi: 10.1016/s0092-8674(03)00722-0.


COP9 Signalosome (CSN) is a fascinating protein complex whose biochemical and physiological functions are only beginning to be understood. It is conserved throughout eukaryotes and is critical to the proper development of all multicellular organisms in which its function has been explored. Recent work suggests that CSN plays a key role in sustaining the activity of SCF and other cullin-based ubiquitin ligases, which may account for its essential roles in development. Here, we summarize what is known about CSN, and discuss hypotheses for how CSN promotes the activity of SCF ubiquitin ligases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • COP9 Signalosome Complex
  • Cell Differentiation / physiology*
  • Cysteine Endopeptidases / genetics
  • Cysteine Endopeptidases / metabolism
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / enzymology*
  • Humans
  • Multienzyme Complexes / genetics
  • Multienzyme Complexes / metabolism
  • Multiprotein Complexes
  • Peptide Hydrolases
  • Peptide Synthases / genetics
  • Peptide Synthases / metabolism*
  • Proteasome Endopeptidase Complex
  • Proteins / genetics
  • Proteins / metabolism*
  • SKP Cullin F-Box Protein Ligases
  • Ubiquitin / genetics
  • Ubiquitin / metabolism


  • Multienzyme Complexes
  • Multiprotein Complexes
  • Proteins
  • Ubiquitin
  • SKP Cullin F-Box Protein Ligases
  • Peptide Hydrolases
  • COP9 Signalosome Complex
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex
  • Peptide Synthases