Long term effects of vaccination of patients deficient in a late complement component with a tetravalent meningococcal polysaccharide vaccine

Vaccine. 2003 Oct 1;21(27-30):4437-47. doi: 10.1016/s0264-410x(03)00440-7.


Of 45 Russian patients with late complement component deficiency (LCCD) who experienced one to five meningococcal infections, 31 were immunised with a meningococcal A/C/W135/Y polysaccharide vaccine and were followed for 3-8 years. Total and immunoglobulin (Ig) class specific concentration of antibodies to meningococcal polysaccharides in sera of LCCD patients increased significantly 1 month after vaccination and remained elevated for 3 years. Revaccination of LCCD patients 3 years after the first dose restored the total Ig concentrations to those observed 1 year after the first vaccination. Six new episodes of meningococcal infection in four patients developed in the group of 31 vaccinees; six episodes in six patients developed in the same time in the group of 14 non-vaccinated LCCD persons. Survival analysis demonstrated the risk to contract meningococcal disease decreased significantly for vaccinees in comparison to non-vaccinees (P<0.05). Vaccination with of meningococcal tetravalent polysaccharide vaccine decreases the risk of meningococcal infection in LCCD patients.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Bacterial / biosynthesis
  • Complement System Proteins / deficiency*
  • Female
  • Follow-Up Studies
  • Humans
  • Immunization, Secondary
  • Immunoglobulin A / biosynthesis
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin M / biosynthesis
  • Kinetics
  • Lipopolysaccharides / adverse effects
  • Lipopolysaccharides / immunology*
  • Male
  • Meningitis, Meningococcal / cerebrospinal fluid
  • Meningitis, Meningococcal / immunology
  • Meningitis, Meningococcal / prevention & control
  • Meningococcal Vaccines / adverse effects
  • Meningococcal Vaccines / immunology*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Serotyping
  • Vaccination*


  • Antibodies, Bacterial
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Lipopolysaccharides
  • Meningococcal Vaccines
  • Complement System Proteins