Titin: properties and family relationships

Nat Rev Mol Cell Biol. 2003 Sep;4(9):679-89. doi: 10.1038/nrm1198.

Abstract

In striated muscles, the rapid production of macroscopic levels of force and displacement stems directly from highly ordered and hierarchical protein organization, with the sarcomere as the elemental contractile unit. There is now a wealth of evidence indicating that the giant elastic protein titin has important roles in controlling the structure and extensibility of vertebrate muscle sarcomeres.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Connectin
  • Cytoskeleton / metabolism
  • Humans
  • Microscopy, Electron
  • Multigene Family*
  • Muscle Proteins / genetics
  • Muscle Proteins / metabolism*
  • Muscle Proteins / ultrastructure
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / ultrastructure
  • Protein Kinases / genetics
  • Protein Kinases / metabolism*
  • Protein Kinases / ultrastructure
  • Sarcomeres / metabolism

Substances

  • Connectin
  • Muscle Proteins
  • TTN protein, human
  • Protein Kinases