Nuclear and unclear functions of SUMO

Nat Rev Mol Cell Biol. 2003 Sep;4(9):690-9. doi: 10.1038/nrm1200.


Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that face nucleate cells, including the control of nucleocytoplasmic signalling and transport and the faithful replication of a large and complex genome, as well as the regulation of gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism*
  • Humans
  • SUMO-1 Protein / physiology*
  • Transcription, Genetic / physiology


  • SUMO-1 Protein