Phosphatases in cell-matrix adhesion and migration

Nat Rev Mol Cell Biol. 2003 Sep;4(9):700-11. doi: 10.1038/nrm1199.


Many proteins that have been implicated in cell-matrix adhesion and cell migration are phosphorylated, which regulates their folding, enzymatic activities and protein-protein interactions. Although modulation of cell motility by kinases is well known, increasing evidence confirms that phosphatases are essential at each stage of the migration process. Phosphatases can control the formation and maintenance of the actin cytoskeleton, regulate small GTPase molecular switches, and modulate the dynamics of matrix-adhesion interaction, actin contraction, rear release and migratory directionality.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Cell Movement / physiology*
  • Cell-Matrix Junctions / metabolism*
  • Humans
  • Monomeric GTP-Binding Proteins / metabolism
  • Phosphoric Monoester Hydrolases / metabolism*


  • Actins
  • Phosphoric Monoester Hydrolases
  • Monomeric GTP-Binding Proteins