Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects

Eur J Clin Nutr. 2003 Oct;57(10):1268-74. doi: 10.1038/sj.ejcn.1601684.


Objective: To study the effects of 13 weeks conjugated linoleic acid (CLA) supplementation in overweight subjects on body-weight maintenance, parameters of appetite and energy intake (EI) at breakfast after weight loss.

Design: This study had a double-blind, placebo-controlled randomized design.

Subjects: A total of 26 men and 28 women (age 37.8+/-7.7 y; body mass index 27.8+/-1.5 kg/m(2)).

Interventions: Subjects were first submitted to a very-low-calorie diet (VLCD; 2.1 MJ/day) for 3 weeks after which they started with the 13-week intervention period. They either received 1.8 g CLA or placebo per day or 3.6 g CLA or placebo per day. Additionally, subjects of the high dosage intervention replaced their habitual lunch by one meal of a protein-rich, low-energy supplement. EI was measured at breakfast and appetite profile after an overnight fast.

Results: The mean body weight loss was 6.9+/-1.7% of their original body weight. Multiple regression analysis showed that at the end of the 13-week intervention, CLA did not have an effect on body weight regain. Feelings of fullness and satiety were increased and feelings of hunger were decreased after 13 weeks intervention by CLA compared to placebo, independent of %body weight regain. However, EI measured at breakfast was not affected by CLA.

Conclusion: Appetite (hunger, satiety and fullness) was favorably, dose-independently affected by a 13-week consumption of 1.8 or 3.6 g CLA/day. This did not result in a lower EI at breakfast or an improved body-weight maintenance after weight loss.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Appetite / drug effects*
  • Diet, Reducing*
  • Dietary Supplements
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Eating / drug effects
  • Energy Intake / drug effects*
  • Female
  • Humans
  • Linoleic Acids, Conjugated / administration & dosage*
  • Linoleic Acids, Conjugated / pharmacology
  • Male
  • Middle Aged
  • Obesity / diet therapy*
  • Satiation / drug effects
  • Weight Loss


  • Linoleic Acids, Conjugated