The Alb3/Oxa1/YidC protein family: membrane-localized chaperones facilitating membrane protein insertion?

Trends Cell Biol. 2003 Oct;13(10):510-6. doi: 10.1016/j.tcb.2003.08.005.


The recently identified Alb3/Oxa1/YidC family constitutes a novel class of proteins that function in promoting membrane insertion in chloroplasts, mitochondria and bacteria. These proteins mediate membrane insertion of a diverse group of membrane proteins that range from phage coat proteins in bacteria and respiratory-chain protein subunits in mitochondria to the light-harvesting chlorophyll-binding proteins in chloroplasts. Here, we discuss the Alb3/Oxa1/YidC protein family and their possible function as membrane chaperones, helping newly synthesized proteins to fold into the membrane bilayer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Arabidopsis Proteins / chemistry
  • Arabidopsis Proteins / metabolism*
  • Electron Transport Complex IV
  • Escherichia coli Proteins / chemistry
  • Escherichia coli Proteins / metabolism*
  • Membrane Proteins / metabolism*
  • Membrane Transport Proteins / chemistry
  • Membrane Transport Proteins / metabolism*
  • Mitochondrial Proteins
  • Molecular Chaperones / chemistry
  • Molecular Chaperones / metabolism*
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / metabolism*


  • ALBINO 3 protein, Arabidopsis
  • Arabidopsis Proteins
  • Escherichia coli Proteins
  • Membrane Proteins
  • Membrane Transport Proteins
  • Mitochondrial Proteins
  • Molecular Chaperones
  • Nuclear Proteins
  • OXA1 protein
  • YIDC protein, E coli
  • Electron Transport Complex IV