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, 11 (12), 972-4

Recurrent Triploidy of Maternal Origin

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Recurrent Triploidy of Maternal Origin

Francesco Brancati et al. Eur J Hum Genet.

Abstract

Triploidy is the most frequent chromosome aberration in first trimester spontaneous abortions. In contrast to aneuploidies due to nondisjunction, increased maternal age is not a risk factor and the mechanism of triploidy remains poorly understood. To date, recurrence of triploidy of maternal origin has been described only in a few families suggesting some underlying genetic factors. Here, we report on a woman who underwent three consecutive triploid pregnancies, in two of which maternal origin of triploidy was proved by molecular analysis.

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