Extensive-stage small-cell lung cancer

Semin Surg Oncol. 2003;21(3):164-75. doi: 10.1002/ssu.10034.


Extensive-stage small-cell lung cancer (ES-SCLC) continues to be a difficult management issue. While response rates to therapy are relatively high, durable responses are rare, and long-term survival rates are dismal. Although many attempts have been made to develop new therapies, cisplatin-based combination chemotherapy remains the mainstay in the management of these patients. In this review we highlight recent developments in the treatment and management of this malignancy, and discuss future prospects in treatment.

Publication types

  • Review

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Carboplatin / administration & dosage
  • Carcinoma, Small Cell / drug therapy*
  • Carcinoma, Small Cell / pathology
  • Carcinoma, Small Cell / radiotherapy
  • Cisplatin / administration & dosage
  • Cranial Irradiation
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / radiotherapy
  • Middle Aged
  • Neoplasm Staging*
  • Prognosis


  • Carboplatin
  • Cisplatin