Inhaled nitric oxide therapy in neonatal hypoxic respiratory failure: insights beyond primary outcomes

Semin Perinatol. 2003 Aug;27(4):311-9. doi: 10.1016/s0146-0005(03)00043-0.


The Neonatal Research Network developed and initiated 3 multicenter randomized controlled clinical trials evaluating inhaled nitric oxide therapy. Additional projects evolved from these efforts including basic science research and observational investigations. This article provides a historical prospective of the Network's investigations related to the diagnosis and management of neonatal hypoxic respiratory failure, especially those related to inhaled nitric oxide therapy. It will review the Network's contributions toward advancing the clinical care of the newborn with severe hypoxic respiratory failure.

Publication types

  • Review

MeSH terms

  • Administration, Inhalation
  • Bronchodilator Agents / administration & dosage*
  • Canada
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Multicenter Studies as Topic
  • National Institutes of Health (U.S.)
  • Nitric Oxide / administration & dosage*
  • Persistent Fetal Circulation Syndrome / drug therapy*
  • Randomized Controlled Trials as Topic
  • United States


  • Bronchodilator Agents
  • Nitric Oxide