Radionuclide synovectomy and chronic haemophilic synovitis in Asians: a retrospective study

Haemophilia. 2003 Sep;9(5):632-7. doi: 10.1046/j.1365-2516.2003.00799.x.


Radionuclide synovectomy has been identified as the procedure of choice in treating chronic haemophilic synovitis among Caucasian populations. Its effectiveness among East Asians has not been studied. A retrospective study was carried out on 12 Asian haemophiliacs who underwent 12 radionuclide synovectomies. The average follow-up was 30.7 months (range 6-55) for primary procedures. 32P chromic phosphate and 188Re-tin colloid were injected into target joints according to protocol. There was a significant 80% decrease in the median frequency of haemarthrosis from 1.4 per month (range 0.2-7.0) to 0.25 per month (range 0.0-1.8) (P<0.05). Half of the patients had excellent results by 1 year of synovectomy. The median factor usage for target joint haemarthrosis postsynovectomy was 792 units per month (range 0-3209) reduced significantly from a presynovectomy level of 1452 units per month (range 306-7125) (P<0.05). Patients also reported a reduction in joint pain scores, and an improvement in joint mobility and quality of life. The majority of patients were satisfied with the overall outcome of radionuclide synovectomy. Radionuclide synovectomy appears to be effective in reducing the incidence of target joint haemarthrosis and quantity of factor usage for such bleeds among Asians with haemophilic synovitis.

MeSH terms

  • Adolescent
  • Adult
  • Chronic Disease
  • Follow-Up Studies
  • Hemarthrosis / prevention & control
  • Hemophilia A / complications*
  • Hemophilia A / ethnology
  • Hemophilia B / complications*
  • Hemophilia B / ethnology
  • Humans
  • Male
  • Middle Aged
  • Pain Measurement
  • Patient Satisfaction
  • Phosphorus Radioisotopes / therapeutic use
  • Quality of Life
  • Radioisotopes / therapeutic use
  • Retrospective Studies
  • Rhenium / therapeutic use
  • Severity of Illness Index
  • Singapore
  • Synovial Membrane / radiation effects
  • Synovitis / etiology
  • Synovitis / radiotherapy*
  • Treatment Outcome


  • Phosphorus Radioisotopes
  • Radioisotopes
  • Rhenium