Randomised controlled short-term intervention pilot study on rye bran bread in prostate cancer

Eur J Cancer Prev. 2003 Oct;12(5):407-15. doi: 10.1097/00008469-200310000-00010.


The short-term effects of rye bran bread intake in prostate cancer were investigated. Ten men with conservatively treated prostate cancer were randomised to a daily supplement of 295 g of rye bran bread and eight men to 275 g of wheat bread (control) with similar fibre content for three weeks. Blood samples, ultrasound-guided core biopsies of the prostate, and urine samples were taken. In the rye group, there was a significant increase in plasma enterolactone, and the apoptotic index increased significantly from 2.1% (SD 1.3) to 5.9% (SD 1.8), P<0.005 as measured by a TUNEL index in four cases in the rye group and seven cases in the control group. Besides a significant decrease in weight in both groups, only small changes were observed in plasma concentrations of prostate specific antigen (PSA), circulating sex hormones, excreted oestrogens, insulin-like growth factor (IGF)-I, and in the endothelial fibrinolytical system. High intake of rye bran bread is suggested to increase apoptosis in prostate tumours.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Apoptosis*
  • Bread*
  • Cell Division
  • Dietary Fiber
  • Estrogens / pharmacokinetics
  • Gonadal Steroid Hormones / blood
  • Humans
  • Male
  • Middle Aged
  • Prostate-Specific Antigen / analysis
  • Prostatic Neoplasms / blood supply
  • Prostatic Neoplasms / physiopathology*
  • Prostatic Neoplasms / therapy
  • Secale*
  • Somatomedins / analysis
  • Weight Loss


  • Dietary Fiber
  • Estrogens
  • Gonadal Steroid Hormones
  • Somatomedins
  • Prostate-Specific Antigen