Corpus callosum atrophy in adolescents with antecedents of moderate perinatal asphyxia

Brain Inj. 2003 Nov;17(11):1003-9. doi: 10.1080/0269905031000110454.


Background: The corpus callosum (CC) is a cerebral structure that reflects cognitive status in several neurological pathologies. Visual inspection of MRI has shown that hypoxic-ischemic encephalopathy(HIE) causes callosal damage.

Primary objective: To quantify the CC surface in a sample of patients with antecedents of HIE and a group of matched controls.

Research design: Comparisons of CC measures among control subjects, mild HIE patients and moderateHIE patients as well as correlates of CC surface and neuropsychological performance.

Methods: Twenty-one adolescent patients with childhood antecedents of HIE were compared to 21 controls. ANALYZE software was used to semi-automatically measure the CC area.

Main outcomes and results: Patients with moderate HIE showed corpus callosum reduction. The isthmus and genus were the most affected regions. Corpus callosum size correlated with cognitive function.

Conclusions: Corpus callosum quantification provides new evidence of subtle residual deficits in subjects with HIE antecedents without apparent neurological sequelae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Asphyxia Neonatorum / complications*
  • Asphyxia Neonatorum / psychology
  • Atrophy / etiology
  • Atrophy / psychology
  • Case-Control Studies
  • Corpus Callosum / pathology*
  • Female
  • Humans
  • Infant, Newborn
  • Magnetic Resonance Imaging
  • Male
  • Neuropsychological Tests