The effects of tissue sealants, platelet gels, and growth factors on wound healing

Curr Opin Otolaryngol Head Neck Surg. 2003 Aug;11(4):245-50. doi: 10.1097/00020840-200308000-00005.


The improved understanding of wound healing has resulted in the rapid expansion of tissue adhesives, platelet gels, and the use of growth factors. Tissue sealants have been used to close incisions, seal and secure skin flaps, as well as promote hemostasis. Platelet gels have multiple uses that take advantage of their inherent clot-forming ability as well as their potential to release growth factors. Recombinant platelet-derived growth factor has been studied extensively for the treatment of chronic dermal ulcers and shows promise in enhancing wound care. This article will address some recent advancements related to the expanding use of tissue sealants and growth factors to enhance wound healing within the head and neck area.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Platelets / physiology*
  • Gels / pharmacology*
  • Gels / therapeutic use
  • Growth Substances / pharmacology*
  • Growth Substances / therapeutic use
  • Head
  • Humans
  • Neck
  • Tissue Adhesives / pharmacology*
  • Tissue Adhesives / therapeutic use
  • Wound Healing / drug effects*
  • Wound Healing / physiology
  • Wounds and Injuries / therapy*


  • Gels
  • Growth Substances
  • Tissue Adhesives