Punctal-canalicular stenosis associated with mitomycin-C for corneal epithelial dysplasia

Am J Ophthalmol. 2003 Oct;136(4):746-7. doi: 10.1016/s0002-9394(03)00393-3.


Purpose: To report a case of punctal-canalicular stenosis after topical mitomycin C use for corneal dysplasia. To the authors' knowledge, this association has not previously been described.

Design: Observational case report.

Method: A 62-year-old woman was noted to have a right inferotemporal corneal dysplastic lesion. She received a topical course of mitomycin-C 0.04% four times a day, which subsequently invoked a toxoallergic reaction. One month later, the patient developed right-sided epiphora.

Results: Probing demonstrated complete stenosis of the right lower canaliculus, 5 mm from the punctum.

Conclusion: Mitomycin-C use may lead to lacrimal apparatus fibrosis and symptomatic epiphora when inciting a toxoallergic reaction.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Antibiotics, Antineoplastic / adverse effects*
  • Corneal Diseases / drug therapy*
  • Female
  • Fibrosis
  • Humans
  • Lacrimal Duct Obstruction / chemically induced*
  • Lacrimal Duct Obstruction / diagnosis
  • Middle Aged
  • Mitomycin / adverse effects*
  • Nasolacrimal Duct / drug effects*
  • Nasolacrimal Duct / pathology


  • Antibiotics, Antineoplastic
  • Mitomycin