Acute hemodynamic effects and home therapy using a novel pulsed nasal nitric oxide delivery system in children and young adults with pulmonary hypertension

Am J Cardiol. 2003 Oct 1;92(7):886-90. doi: 10.1016/s0002-9149(03)00910-x.


In 26 patients, we evaluated a novel pulsed nasal delivery system for nitric oxide (NO) that, in the short term, was as effective as continuous delivery for decreasing pulmonary artery pressure and pulmonary vascular resistance. In 2 patients, NO delivered in the home using this pulsing system was well tolerated for up to 2 years. The long-term safety, efficacy, and acceptability of NO delivered in the home remains to be studied.

Publication types

  • Clinical Trial

MeSH terms

  • Administration, Inhalation
  • Administration, Intranasal
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Hemodynamics / drug effects*
  • Home Nursing / methods*
  • Humans
  • Hypertension, Pulmonary / drug therapy*
  • Hypertension, Pulmonary / physiopathology*
  • Male
  • Nitric Oxide / administration & dosage*
  • Pulse Therapy, Drug / instrumentation
  • Pulse Therapy, Drug / methods
  • Time
  • Treatment Outcome
  • Vasodilator Agents / administration & dosage*


  • Vasodilator Agents
  • Nitric Oxide