D-cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task

Eur J Pharmacol. 1992 Nov 24;224(1):97-8. doi: 10.1016/0014-2999(92)94825-g.


It is shown that D-cycloserine has cognition-enhancing properties in quinolinic acid hippocampal-lesioned rats. Lesioned rats had a severe impairment of working memory in an allocentric spatial reversal paradigm in the 8-arm maze, and performance could be restored with 12 mg/kg i.p. D-cycloserine, given 30 min before testing. The present findings favour the testing of D-cycloserine for clinical efficacy in patients with Alzheimer's disease with loss of pyramidal neurons and disconnected glycine-NMDA receptor activation.

MeSH terms

  • Analysis of Variance
  • Animals
  • Cognition Disorders / drug therapy*
  • Cycloserine / pharmacology*
  • Hippocampus / drug effects*
  • Male
  • Memory Disorders / drug therapy*
  • Quinolinic Acid / toxicity
  • Rats
  • Rats, Sprague-Dawley


  • Cycloserine
  • Quinolinic Acid