Gluconeogenesis from methylglyoxal in isolated murine hepatocytes. Does an alternative pathway exist in which pyruvate is not an intermediate?

P Riba; T Garzó; J Mandl; M P Kalapos

doi:10.1016/0020-711x(92)90119-l

Gluconeogenesis from methylglyoxal in isolated murine hepatocytes. Does an alternative pathway exist in which pyruvate is not an intermediate?

Int J Biochem. 1992 Nov;24(11):1721-4. doi: 10.1016/0020-711x(92)90119-l.

Authors

P Riba¹, T Garzó, J Mandl, M P Kalapos

Affiliation

¹ Semmelweis University, Medical School, First Institute of Biochemistry, Budapest, Hungary.

PMID: 1451907
DOI: 10.1016/0020-711x(92)90119-l

Abstract

1. Gluconeogenesis from alanine can be prevented by the addition of monoiodo acetic acid (an inhibitor of glyceraldehyde 3-phosphate dehydrogenase), while glucose production from methylglyoxal is only partially inhibited by this compound. 2. It is supposed that methylglyoxal can enter gluconeogenic sequence not only at pyruvate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cells, Cultured
Gluconeogenesis*
Liver / metabolism*
Mice
Pyruvaldehyde / metabolism*
Pyruvates / metabolism

Substances

Pyruvates
Pyruvaldehyde