An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Genome Biol. 2003;4(10):R69. doi: 10.1186/gb-2003-4-10-r69. Epub 2003 Sep 11.


We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Binding Sites
  • Chromatin / metabolism
  • Databases, Genetic*
  • Gene Expression Regulation*
  • Genes / genetics*
  • Genomics*
  • Humans
  • Internet
  • Neoplasms / genetics
  • Phylogeny
  • Precipitin Tests
  • Proto-Oncogene Proteins c-myc / metabolism*
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Substrate Specificity
  • Transcription Factors / metabolism*


  • Chromatin
  • Proto-Oncogene Proteins c-myc
  • RNA, Messenger
  • Transcription Factors