Cadherin-mediated cellular signaling

Curr Opin Cell Biol. 2003 Oct;15(5):509-14. doi: 10.1016/s0955-0674(03)00101-7.


Recent cadherin studies focusing on cellular signaling have shown that several pathways are activated by cadherin-mediated cell-cell contact. Cadherin-mediated contacts activate Rho family GTPases, regulate the availability of beta-catenin to participate in Wnt signaling, and function in receptor tyrosine kinase signaling. Although different classical cadherins bind to the same cytosolic proteins via their cytoplasmic tails, one message that is clear from the recent literature is that downstream signals emanating from cadherin-mediated contacts are both cadherin-specific and cell-context-specific.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cadherins / metabolism*
  • Cell Adhesion
  • Cell Adhesion Molecules / metabolism*
  • Cytoskeletal Proteins / metabolism*
  • Humans
  • Phosphorylation
  • Protein-Tyrosine Kinases / metabolism
  • Proto-Oncogene Proteins / metabolism
  • Signal Transduction / physiology*
  • Trans-Activators / metabolism*
  • Vascular Endothelial Growth Factor A / metabolism
  • Wnt Proteins
  • Zebrafish Proteins*
  • alpha Catenin
  • beta Catenin
  • rho GTP-Binding Proteins / metabolism*


  • CTNNA1 protein, human
  • CTNNB1 protein, human
  • Cadherins
  • Cell Adhesion Molecules
  • Cytoskeletal Proteins
  • Proto-Oncogene Proteins
  • Trans-Activators
  • Vascular Endothelial Growth Factor A
  • Wnt Proteins
  • Zebrafish Proteins
  • alpha Catenin
  • beta Catenin
  • Protein-Tyrosine Kinases
  • rho GTP-Binding Proteins