Integrin signaling to the actin cytoskeleton

Curr Opin Cell Biol. 2003 Oct;15(5):572-82. doi: 10.1016/s0955-0674(03)00109-1.

Abstract

Integrin engagement stimulates the activity of numerous signaling molecules, including the Rho family of GTPases, tyrosine phosphatases, cAMP-dependent protein kinase and protein kinase C, and stimulates production of PtdIns(4,5)P2. Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins / metabolism*
  • Animals
  • Cyclic AMP-Dependent Protein Kinases
  • Cytoskeleton / metabolism*
  • Enzyme Activation / physiology
  • Humans
  • Integrins / metabolism*
  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositol Phosphates / metabolism
  • Protein Kinase C / metabolism
  • Protein Tyrosine Phosphatases / metabolism
  • Protein-Serine-Threonine Kinases / metabolism
  • Signal Transduction / physiology*
  • cdc42 GTP-Binding Protein / metabolism
  • rac GTP-Binding Proteins / metabolism
  • rho GTP-Binding Proteins / metabolism

Substances

  • Actins
  • Integrins
  • Phosphatidylinositol 4,5-Diphosphate
  • Phosphatidylinositol Phosphates
  • Protein-Serine-Threonine Kinases
  • Cyclic AMP-Dependent Protein Kinases
  • Protein Kinase C
  • Protein Tyrosine Phosphatases
  • cdc42 GTP-Binding Protein
  • rac GTP-Binding Proteins
  • rho GTP-Binding Proteins