Synaptic Adhesion Molecules

Curr Opin Cell Biol. 2003 Oct;15(5):621-32. doi: 10.1016/s0955-0674(03)00107-8.

Abstract

Formation, differentiation and plasticity of synapses, the specialized cell-cell contacts through which neurons communicate, all require interactions between pre- and post-synaptic partners. Several synaptically localized adhesion molecules potentially capable of mediating these interactions have been identified recently. Functional studies suggest roles for some of them in target recognition (e.g. SYG-1 and sidekicks), formation and alignment of synaptic specializations (e.g. SynCAM, neuroligin and neurexin), and regulation of synaptic structure and function (e.g. cadherins and syndecan).

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence / physiology
  • Animals
  • Axons / metabolism
  • Cadherins / metabolism
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism
  • Cell Adhesion Molecules / metabolism*
  • Cytoskeleton / metabolism*
  • GTP-Binding Proteins / metabolism
  • Immunoglobulins / genetics
  • Immunoglobulins / metabolism
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Neural Cell Adhesion Molecules / genetics
  • Neural Cell Adhesion Molecules / metabolism
  • Protein Structure, Tertiary
  • Synapses / metabolism*
  • Synaptic Transmission / physiology*
  • Synaptic Vesicles / metabolism

Substances

  • Bsn protein, rat
  • Cadherins
  • Caenorhabditis elegans Proteins
  • Cell Adhesion Molecules
  • Immunoglobulins
  • Nerve Tissue Proteins
  • Neural Cell Adhesion Molecules
  • Rim protein, mammalian
  • Rim1 protein, rat
  • SYG-1 protein, C elegans
  • GTP-Binding Proteins