Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms?

Biol Cell. 2003 Sep;95(6):329-33. doi: 10.1016/s0248-4900(03)00081-9.


Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions, may contribute to the human pathology. A review of changes in cellular and synaptic function and connectivity after de-afferentation suggests this epileptic syndrome may involve a pathological replay of developmental mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Brain / embryology*
  • Chlorides / metabolism
  • Electroencephalography
  • Epilepsy / pathology*
  • Epilepsy, Temporal Lobe / embryology*
  • Epilepsy, Temporal Lobe / pathology*
  • Hippocampus / pathology
  • Humans
  • Sclerosis / pathology
  • Signal Transduction
  • Synapses / metabolism
  • Temporal Lobe / pathology*
  • gamma-Aminobutyric Acid / metabolism


  • Chlorides
  • gamma-Aminobutyric Acid