Electrochemical DNA sensors

Nat Biotechnol. 2003 Oct;21(10):1192-9. doi: 10.1038/nbt873.


Electrochemistry-based sensors offer sensitivity, selectivity and low cost for the detection of selected DNA sequences or mutated genes associated with human disease. DNA-based electrochemical sensors exploit a range of different chemistries, but all take advantage of nanoscale interactions between the target in solution, the recognition layer and a solid electrode surface. Numerous approaches to electrochemical detection have been developed, including direct electrochemistry of DNA, electrochemistry at polymer-modified electrodes, electrochemistry of DNA-specific redox reporters, electrochemical amplifications with nanoparticles, and electrochemical devices based on DNA-mediated charge transport chemistry.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biosensing Techniques / instrumentation*
  • Biosensing Techniques / methods
  • Coated Materials, Biocompatible / chemistry*
  • DNA / analysis*
  • DNA / chemistry*
  • Electrochemistry / instrumentation*
  • Electrochemistry / methods
  • Equipment Design
  • Membranes, Artificial
  • Nanotechnology / instrumentation*
  • Nanotechnology / methods
  • Proteins / analysis*
  • Transducers*


  • Coated Materials, Biocompatible
  • Membranes, Artificial
  • Proteins
  • DNA