A big step in the study of small cell lung cancer

Cancer Cell. 2003 Sep;4(3):163-6. doi: 10.1016/s1535-6108(03)00221-6.


A rationally designed, conditional p53 and Rb allele-based and lung-targeted mouse model of human small cell lung cancer (SCLC) provides the cancer research community with a valid and important new tool to use in translational research against this deadly disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alleles
  • Animals
  • Carcinoma, Small Cell / genetics*
  • Carcinoma, Small Cell / pathology
  • Genes, Retinoblastoma / genetics*
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Mice
  • Models, Animal
  • Mutation
  • Neoplasm Metastasis
  • Tumor Suppressor Protein p53 / genetics*


  • Tumor Suppressor Protein p53