Effect of HIV-1 antiretroviral drugs on cytoadherence and phagocytic clearance of Plasmodium falciparum-parasitised erythrocytes

Lancet. 2003 Sep 27;362(9389):1039-41. doi: 10.1016/S0140-6736(03)14414-5.

Abstract

In response to the HIV/AIDS pandemic, antiretroviral treatment is currently being implemented in sub-Saharan Africa, where malaria and HIV-1 co-infections are highly prevalent. The effectiveness and tolerability of antiretrovirals in patients with malaria and HIV-1 co-infection have not been investigated. Antiretrovirals decrease CD36 surface concentrations in vivo, which might impair receptor function and affect parasite-host interactions. Thus, we investigated the effects of these drugs on CD36-mediated cytoadherence and non-opsonic phagocytosis of Plasmodium falciparum parasitised erythrocytes in vitro. The protease-inhibitor class of antiretrovirals particularly impairs CD36-mediated cytoadherence and non-opsonic phagocytosis of parasitised erythrocytes by human macrophages. Such treatment might therefore contribute to altered malaria disease outcomes in co-infected patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa South of the Sahara / epidemiology
  • Animals
  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / therapeutic use*
  • Cell Adhesion / drug effects
  • Cell Adhesion / immunology
  • Cell Adhesion / physiology
  • Comorbidity
  • Erythrocytes / parasitology
  • HIV Infections / drug therapy*
  • HIV Infections / epidemiology
  • HIV Infections / immunology
  • HIV Protease Inhibitors / adverse effects
  • HIV Protease Inhibitors / pharmacology
  • HIV Protease Inhibitors / therapeutic use
  • HIV-1*
  • Host-Parasite Interactions / drug effects
  • Host-Parasite Interactions / immunology
  • Humans
  • Intercellular Adhesion Molecule-1 / analysis
  • Intercellular Adhesion Molecule-1 / immunology
  • Malaria, Falciparum / blood
  • Malaria, Falciparum / epidemiology*
  • Malaria, Falciparum / immunology
  • Phagocytosis / drug effects
  • Phagocytosis / immunology
  • Phagocytosis / physiology
  • Plasmodium falciparum / parasitology
  • Receptors, Complement 3b / analysis
  • Receptors, Complement 3b / immunology

Substances

  • Anti-HIV Agents
  • HIV Protease Inhibitors
  • Receptors, Complement 3b
  • Intercellular Adhesion Molecule-1