Abstract
In response to the HIV/AIDS pandemic, antiretroviral treatment is currently being implemented in sub-Saharan Africa, where malaria and HIV-1 co-infections are highly prevalent. The effectiveness and tolerability of antiretrovirals in patients with malaria and HIV-1 co-infection have not been investigated. Antiretrovirals decrease CD36 surface concentrations in vivo, which might impair receptor function and affect parasite-host interactions. Thus, we investigated the effects of these drugs on CD36-mediated cytoadherence and non-opsonic phagocytosis of Plasmodium falciparum parasitised erythrocytes in vitro. The protease-inhibitor class of antiretrovirals particularly impairs CD36-mediated cytoadherence and non-opsonic phagocytosis of parasitised erythrocytes by human macrophages. Such treatment might therefore contribute to altered malaria disease outcomes in co-infected patients.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Africa South of the Sahara / epidemiology
-
Animals
-
Anti-HIV Agents / adverse effects
-
Anti-HIV Agents / pharmacology
-
Anti-HIV Agents / therapeutic use*
-
Cell Adhesion / drug effects
-
Cell Adhesion / immunology
-
Cell Adhesion / physiology
-
Comorbidity
-
Erythrocytes / parasitology
-
HIV Infections / drug therapy*
-
HIV Infections / epidemiology
-
HIV Infections / immunology
-
HIV Protease Inhibitors / adverse effects
-
HIV Protease Inhibitors / pharmacology
-
HIV Protease Inhibitors / therapeutic use
-
HIV-1*
-
Host-Parasite Interactions / drug effects
-
Host-Parasite Interactions / immunology
-
Humans
-
Intercellular Adhesion Molecule-1 / analysis
-
Intercellular Adhesion Molecule-1 / immunology
-
Malaria, Falciparum / blood
-
Malaria, Falciparum / epidemiology*
-
Malaria, Falciparum / immunology
-
Phagocytosis / drug effects
-
Phagocytosis / immunology
-
Phagocytosis / physiology
-
Plasmodium falciparum / parasitology
-
Receptors, Complement 3b / analysis
-
Receptors, Complement 3b / immunology
Substances
-
Anti-HIV Agents
-
HIV Protease Inhibitors
-
Receptors, Complement 3b
-
Intercellular Adhesion Molecule-1