Preferential attachment in the protein network evolution

Phys Rev Lett. 2003 Sep 26;91(13):138701. doi: 10.1103/PhysRevLett.91.138701. Epub 2003 Sep 26.

Abstract

The Saccharomyces cerevisiae protein-protein interaction map, as well as many natural and man-made networks, shares the scale-free topology. The preferential attachment model was suggested as a generic network evolution model that yields this universal topology. However, it is not clear that the model assumptions hold for the protein interaction network. Using a cross-genome comparison, we show that (a) the older a protein, the better connected it is, and (b) the number of interactions a protein gains during its evolution is proportional to its connectivity. Therefore, preferential attachment governs the protein network evolution. Evolutionary mechanisms leading to such preference and some implications are discussed.

MeSH terms

  • Evolution, Molecular*
  • Genome, Fungal
  • Models, Biological
  • Phylogeny
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / genetics*
  • Saccharomyces cerevisiae Proteins / metabolism

Substances

  • Saccharomyces cerevisiae Proteins