Cell biology of the presynaptic terminal

Annu Rev Neurosci. 2003;26:701-28. doi: 10.1146/annurev.neuro.26.041002.131445.


The chemical synapse is a specialized intercellular junction that operates nearly autonomously to allow rapid, specific, and local communication between neurons. Focusing our attention on the presynaptic terminal, we review the current understanding of how synaptic morphology is maintained and then the mechanisms in synaptic vesicle exocytosis and recycling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion / physiology*
  • Cells, Cultured
  • Endocytosis / physiology
  • Exocytosis / physiology
  • Neuronal Plasticity
  • Presynaptic Terminals / metabolism*
  • Presynaptic Terminals / physiology
  • Synaptic Vesicles / metabolism*
  • Transport Vesicles / physiology