Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Sep;12(3):541-52.
doi: 10.1016/s1097-2765(03)00350-2.

An Open-And-Shut Case? Recent Insights Into the Activation of EGF/ErbB Receptors

Affiliations
Free article
Review

An Open-And-Shut Case? Recent Insights Into the Activation of EGF/ErbB Receptors

Antony W Burgess et al. Mol Cell. .
Free article

Abstract

Recent crystallographic studies have provided significant new insight into how receptor tyrosine kinases from the EGF receptor or ErbB family are regulated by their growth factor ligands. EGF receptor dimerization is mediated by a unique dimerization arm, which becomes exposed only after a dramatic domain rearrangement is promoted by growth factor binding. ErbB2, a family member that has no ligand, has its dimerization arm constitutively exposed, and this explains several of its unique properties. We outline a mechanistic view of ErbB receptor homo- and heterodimerization, which suggests new approaches for interfering with these processes when they are implicated in human cancers.

Similar articles

See all similar articles

Cited by 280 articles

See all "Cited by" articles

LinkOut - more resources

Feedback