Applied introduction to multivariate methods used in drug discovery

Mini Rev Med Chem. 2003 Dec;3(8):831-48. doi: 10.2174/1389557033487674.


The number of articles concerning optimization and applications of multivariate techniques in drug discovery testifies the growing importance attributed to these methods. This mini review focuses on some of the basic and most employed multivariate techniques in drug discovery research. Examples from the literature were selected to illustrate a number of potential applications.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / chemistry
  • Blood-Brain Barrier / chemistry
  • Chemistry, Pharmaceutical
  • Combinatorial Chemistry Techniques / methods
  • Drug Design*
  • Multivariate Analysis*
  • Pharmaceutical Preparations / chemistry
  • Research Design


  • Antineoplastic Agents
  • Pharmaceutical Preparations