Abstract
Activity-guided fractionation of a root extract of Caesalpinia pulcherrima led to the isolation of two cassane-furanoditerpenoids, 6 beta-benzoyl-7 beta-hydroxyvouacapen-5 alpha-ol (1) and 6 beta-cinnamoyl-7beta-hydroxyvouacapen-5 alpha-ol (2). Compound 2 showed strong antitubercular activity with a minimum inhibitory concentration (MIC) of 6.25 microg/mL, whereas the benzoyl analogue (1) was less active (MIC 25 microg/mL). Both compounds expressed moderate cytotoxic activity towards KB (human oral carcinonoid cancer), BC (human breast cancer) and NCl-H187 (small cell lung cancer) cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Antitubercular Agents / administration & dosage
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Antitubercular Agents / pharmacology*
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Antitubercular Agents / therapeutic use
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Caesalpinia*
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Cell Line, Tumor / drug effects
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Diterpenes / administration & dosage
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Diterpenes / pharmacology*
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Diterpenes / therapeutic use
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Humans
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Roots
Substances
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Antineoplastic Agents, Phytogenic
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Antitubercular Agents
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Diterpenes
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Plant Extracts