An antiplatelet aggregation principle and X-ray structural analysis of cis-khellactone diester from Peucedanum japonicum

J Nat Prod. 1992 Oct;55(10):1396-401. doi: 10.1021/np50088a002.

Abstract

Three structurally related khellactone coumarins, 1-3, were isolated from the aerial parts of Peucedanum japonicum (Umbelliferae). Compound 2 was identified as a new coumarin (cis-3'-isovaleryl-4'-senecioylkhellactone) by spectral and chemical analysis. Conformation of the dihydropyrano ring of cis-3',4'-disenecioylkhellactone [3] was elucidated by X-ray crystallographic analysis. These three natural khellactone esters were subjected to the antiplatelet aggregation bioassay where cis-3',4'-diisovalerylkhellactone [1] showed significant activity (at 50 micrograms/ml).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Coumarins / chemistry*
  • Coumarins / isolation & purification
  • Coumarins / pharmacology*
  • Drugs, Chinese Herbal*
  • Magnetic Resonance Spectroscopy
  • Plants, Medicinal / chemistry*
  • Platelet Aggregation Inhibitors / chemistry*
  • Platelet Aggregation Inhibitors / isolation & purification
  • Platelet Aggregation Inhibitors / pharmacology*
  • Rabbits
  • X-Ray Diffraction

Substances

  • Coumarins
  • Drugs, Chinese Herbal
  • Platelet Aggregation Inhibitors