[Sildenafil as a substitute for subcutaneous prostacyclin in pulmonary hypertension]

Arch Bronconeumol. 2003 Oct;39(10):476-7. doi: 10.1016/s0300-2896(03)75431-3.
[Article in Spanish]


Subcutaneous prostacyclin (treprostinil) is an effective short-term treatment for pulmonary hypertension. The most frequently described adverse effect-pain in the area of injection-rarely requires that treatment be withdrawn. Sildenafil is a selective fosfodiesterase-5 inhibitor with pulmonary vasodilating effects. We describe the use of sildenafil as a substitute for treprostinil in a patient with pulmonary hypertension associated with lupus erythematosus. Treatment with treprostinil was discontinued due to uncontrollable abdominal pain.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Pain / chemically induced
  • Adult
  • Epoprostenol / adverse effects
  • Epoprostenol / analogs & derivatives*
  • Female
  • Humans
  • Hypertension, Pulmonary / drug therapy*
  • Hypertension, Pulmonary / etiology
  • Lupus Erythematosus, Systemic / complications
  • Piperazines / therapeutic use*
  • Purines
  • Sildenafil Citrate
  • Sulfones
  • Vasodilator Agents / adverse effects
  • Vasodilator Agents / therapeutic use*


  • Piperazines
  • Purines
  • Sulfones
  • Vasodilator Agents
  • Sildenafil Citrate
  • Epoprostenol
  • treprostinil