Cerebral cysticercosis by Taenia crassiceps was diagnosed in an adult female domestic shorthair cat. The animal was euthanized 6 weeks after the initial presentation with signs of vomiting, lethargy, and ataxia. The disease took an intermittent relapsing course with the neurological signs progressing eventually to recumbancy and coma. At necropsy, numerous cysticerci were found in the dilated left lateral ventricle and the adjacent brain parenchyma. The cysticerci were identified as metacestodes of T. crassiceps larvae based on size and morphology of the cysts; shape, number, and size of the rostellar hooks; and mode of proliferation, including endogenous and exogenous budding. Cerebral cysticercosis by T. crassiceps is rare in atypical intermediate hosts and has not been described in cats.