Tumor escape from immune response: mechanisms and targets of activity

Curr Drug Targets. 2003 Oct;4(7):525-36. doi: 10.2174/1389450033490849.

Abstract

Immune system plays an important role in control of tumor progression. Effective antitumor immune response depends on close interaction of several elements of immune system. They include antigen-presenting cells, different subsets of T cells, B cells and NK cells. However, tumor cells developed a number of mechanisms to escape recognition and elimination by immune system. In this review we will discuss these mechanisms and address possible approaches to correct them.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Antigen-Presenting Cells / cytology
  • Antigen-Presenting Cells / immunology
  • Cell Differentiation / immunology
  • Humans
  • Immunologic Surveillance
  • Killer Cells, Natural / cytology
  • Killer Cells, Natural / immunology
  • Myeloid Cells / cytology
  • Myeloid Cells / immunology
  • Neoplasms / immunology*
  • Neoplasms / therapy
  • T-Lymphocytes / immunology
  • Tumor Escape / immunology*