In through the out door: nuclear localization of the regulators of G protein signaling

J Neurochem. 2003 Nov;87(3):551-9. doi: 10.1046/j.1471-4159.2003.02047.x.


The regulators of G protein signaling (RGS) are an extraordinary class of diverse multifunctional signaling proteins best known for their potent capacity to down-regulate the activity of Galpha subunits at the plasma membrane. In certain circumstances, some RGS proteins undergo translocation to the nucleus or plasma membrane from the cytoplasm. Translocation demonstrates a potentially dynamic alternative mechanism for Galpha subunit or effector regulation. The nuclear localization of the regulators of G protein signaling proteins further suggests these proteins possess even greater functional heterogeneity than that envisioned previously, as regulators of transcription and cell cycle control.

Publication types

  • Review

MeSH terms

  • Active Transport, Cell Nucleus / physiology
  • Animals
  • Cell Nucleus / metabolism*
  • Cytoplasm / metabolism
  • Humans
  • Models, Biological
  • Neurons / metabolism*
  • Phosphorylation
  • RGS Proteins / metabolism*
  • Signal Transduction / physiology


  • RGS Proteins