Malignant lymphoma of the ocular adnexa associated with the benign lymphoepithelial lesion of the parotid glands. Report of two cases

Ophthalmology. 1992 Oct;99(10):1582-7. doi: 10.1016/s0161-6420(92)31763-4.


Background: The benign lymphoepithelial lesion of the salivary/lacrimal glands is generally regarded as a lymphoproliferative disorder that may be associated with Sjögren syndrome. Although lymphomatous transformation in patients with Sjögren syndrome is well documented, few reports have appeared describing similar findings in patients with a benign lymphoepithelial lesion.

Methods: The authors report the unusual occurrence of malignant lymphoma involving the ocular adnexa in two patients with a histopathologically documented benign lymphoepithelial lesion of the parotid glands.

Results: Both patients developed B-cell lymphomas. The eyelid tumor in case 1 expressed IgM/kappa cell surface markers by flow cytometry, and the orbital/conjunctival masses in case 2 showed neoplastic nodules of B cells that were only immunoreactive to lambda light chains (avidin-biotin complex method).

Conclusion: To the authors' knowledge, this is the first report of ocular adnexal lymphoma arising in patients with a benign lymphoepithelial lesion of the parotid glands. This report establishes that ocular adnexal lymphoma may arise in a patient with a preexisting benign lymphoepithelial lesion.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Conjunctival Neoplasms / diagnostic imaging
  • Conjunctival Neoplasms / pathology*
  • Eyelid Neoplasms / diagnostic imaging
  • Eyelid Neoplasms / pathology*
  • Humans
  • Lymphoma, B-Cell / diagnostic imaging
  • Lymphoma, B-Cell / pathology*
  • Lymphoproliferative Disorders / pathology*
  • Male
  • Orbital Neoplasms / diagnostic imaging
  • Orbital Neoplasms / pathology*
  • Parotid Diseases / pathology*
  • Tomography, X-Ray Computed