Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells

Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11486-9. doi: 10.1073/pnas.89.23.11486.

Abstract

Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Borna disease virus / genetics*
  • Cell Nucleus / microbiology
  • Cells, Cultured
  • Humans
  • In Vitro Techniques
  • Protein Biosynthesis
  • RNA Viruses / genetics*
  • RNA, Messenger / genetics
  • RNA, Viral / genetics*
  • Transcription, Genetic
  • Virus Diseases / genetics*

Substances

  • RNA, Messenger
  • RNA, Viral