Endothelial nitric oxide synthase: a determinant of TNFalpha production by human monocytes/macrophages

Biochem Biophys Res Commun. 2003 Oct 24;310(3):677-80. doi: 10.1016/j.bbrc.2003.09.039.


Until recently endothelial nitric oxide synthase (eNOS) has been associated exclusively with physiological functions, particularly in the cardiovascular system. However, increasing evidence has been accumulated that supports the concept for a role of eNOS in pathophysiology. In particular, detection of eNOS protein and activity in human monocytes/macrophages suggest an immunomodulatory role of this enzyme. Here, we review data that promote the hypothesis that by enhancing TNFalpha production, eNOS activity should be regarded as a novel pro-inflammatory parameter in human monocytes/macrophages.

Publication types

  • Review

MeSH terms

  • Humans
  • Inflammation
  • Macrophages / metabolism
  • Models, Biological
  • Monocytes / enzymology
  • Monocytes / metabolism*
  • Nitric Oxide Synthase / physiology*
  • Nitric Oxide Synthase Type III
  • Tumor Necrosis Factor-alpha / biosynthesis*


  • Tumor Necrosis Factor-alpha
  • NOS3 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type III