Vitamin D3-dependent pathway regulates TACO gene transcription

Biochem Biophys Res Commun. 2003 Oct 24;310(3):876-7. doi: 10.1016/j.bbrc.2003.09.087.

Abstract

Recently, gene coding for tryptophan-aspartate containing coat protein (TACO) has been recognized to play a crucial role in the survival of Mycobacterium tuberculosis within human macrophages. Since regulation of TACO gene is still poorly understood, the present study was addressed to explore the role of vitamins (A, C, D, and E) in TACO gene transcription. Such a study revealed that synergistic action of vitamin D(3) and retinoic acid (RA) had inherent ability to down-regulate TACO gene transcription in human macrophages. Based upon these results, we propose that synergistic action of RA+vitamin D may be of importance in the prevention/control of M. tuberculosis infection.

MeSH terms

  • Cholecalciferol / metabolism*
  • Dose-Response Relationship, Drug
  • Down-Regulation
  • Gene Expression Regulation, Bacterial*
  • Humans
  • Macrophages / metabolism
  • Macrophages / microbiology
  • Microfilament Proteins
  • Mycobacterium tuberculosis / pathogenicity*
  • Polymorphism, Genetic
  • Protein Biosynthesis*
  • Proteins / genetics*
  • RNA / metabolism
  • Receptors, Calcitriol / genetics
  • Transcription, Genetic*
  • Tretinoin / metabolism
  • Vitamin D / metabolism

Substances

  • Microfilament Proteins
  • Proteins
  • Receptors, Calcitriol
  • Vitamin D
  • coronin proteins
  • Cholecalciferol
  • Tretinoin
  • RNA