Chromatin regulation during C. elegans germline development

Curr Opin Genet Dev. 2003 Oct;13(5):455-62. doi: 10.1016/s0959-437x(03)00109-6.


Recent studies in Caenorhabditis elegans implicate PcG- and NuRD-like chromatin regulators in the establishment and maintenance of germline-soma distinctions. Somatic cells appear to utilize NuRD-related nucleosome-remodeling factors to overwrite germline-specific chromatin states that are specified through PcG-like activities. The germline, in turn, may rely on an asymmetrically inherited inhibitor to prevent chromatin reorganization that would otherwise erase pluripotency.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / embryology
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism
  • Chromatin / physiology*
  • Gene Expression Regulation, Developmental / physiology*
  • Germ Cells / growth & development
  • Germ Cells / metabolism*
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism


  • Caenorhabditis elegans Proteins
  • Chromatin
  • Nuclear Proteins
  • pie-1 protein, C elegans