Lancet. 2003 Oct 4;362(9390):1133-41. doi: 10.1016/S0140-6736(03)14471-6.


Autism is a disorder characterised by severe difficulties in social interaction and communication, and with unusual behaviours. Once thought of as rare, autism is now recognised as being common. The role of CNS factors in pathogenesis is suggested by high rates of seizure disorder; research has highlighted the role of several specific brain regions in syndrome pathogenesis. Autism is a strongly genetic disorder and probably arises because of multiple genes; recurrence rates in families with one child are high. Early intervention with various techniques is helpful in many cases. Some pharmacological agents may help with certain problematic behaviours but do not address the underlying cause of the disorder.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adult
  • Autistic Disorder* / diagnosis
  • Autistic Disorder* / genetics
  • Autistic Disorder* / therapy
  • Eye Movements
  • Humans
  • Infant, Newborn
  • Magnetic Resonance Imaging